As we enter the second half of the NFL season, this is where things start to get interesting for everyone and there are numerous story lines. Who is the outright favorite to win the Super Bowl, which may be the obvious; the race for the divisional championships; Rookie of the Year candidates; Pro Bowl selections and those coaches and general managers on the hot seat, not to mention the list of replacements, just to list a few. What a crazy business.

When you look at some of the key matchups this week, New Orleans at Atlanta is a key showdown in the NFC South. In the NFC North, Detroit has cooled off some and will play the Chicago Bears on the road. With a short week for the Bears, the Lions need this game to control the division heading down home stretch.

The New York Giants make the cross-country trek to the city on the bay to battle one of the hottest teams in the NFL, the San Francisco 49ers. And finally the New York Jets take on the visiting New England Patriots. With Tom Brady in a slump, the Patriots have not lost three games in a row for some time. They need their defense to step up against Mark Sanchez and the Jets’ weapons outside the numbers. Monday Night Football will pit the Minnesota Vikings against the Packers at Lambeau Field. Is this the weekend that Green Bay slips and is handed its first defeat?

Softli’s Week 10 Picks

Pittsburgh @ Cincinnati = Steelers

Denver @ Kansas City = Broncos

Jacksonville @ Indianapolis = Jaguars

Buffalo @ Dallas = Cowboys

Houston @ Tampa Bay = Buccaneers

Tennessee @ Carolina = Panthers

Washington @ Miami = Dolphins

New Orleans @ Atlanta = Falcons

Detroit @ Chicago = Lions

St. Louis @ Cleveland = Rams

Arizona @ Philadelphia = Eagles

Baltimore @ Seattle = Ravens

New York Giants @ San Francisco = 49ers

New England @ New York Jets = Patriots

Monday Night Football

Minnesota @ Green Bay = Packers